Energy-sensing molecule RORγ regulates cholesterol metabolism and immune signaling in diabetic kidney disease and aging - PubMed
3 days ago
- #diabetic kidney disease
- #cholesterol metabolism
- #immune signaling
- RORγ is downregulated in diabetic and aged kidneys.
- Tubule-specific RORγ deficiency worsens kidney injury, while its overexpression protects.
- RORγ stabilizes INSIG1 by upregulating YOD1 and enhancing AMPK activity via CAB39.
- Stabilized INSIG1 blocks SREBP2 (cholesterol synthesis) and STING (inflammatory signaling).
- In diabetes, RORγ is suppressed by CTCF and impaired AMPK/SIRT1 signaling.
- RORγ agonists or RORγ-enriched exosomes alleviate diabetic kidney injury.
- RORγ co-regulates AMPK-mediated metabolic and STING-driven immune pathways through INSIG1 stabilization.