Canonical MAPK signaling in auditory neuropathy - PubMed
8 days ago
- #Auditory Neuropathy
- #Hearing Loss
- #MAPK Signaling
- Auditory neuropathy (AN) is a form of hearing loss affecting inner hair cells (IHCs), ribbon synapses, and spiral ganglion neurons (SGNs).
- There is a lack of targeted therapy for AN, necessitating better understanding of its pathogenic mechanisms.
- Mitogen-activated protein kinase (MAPK) signaling plays a role in AN pathogenesis, with alterations observed in IHCs, SGNs, and ribbon synapses.
- ERK/MAPK alterations occur in IHCs and SGNs, while p38 and JNK modulations are found in ribbon synapses and SGNs.
- MAPK signaling represents a potential therapeutic target for AN treatment development.