Polypharmacy, anticholinergic burden and inflammation in relation to accelerated biological ageing - PubMed
2 days ago
- #polypharmacy
- #inflammation
- #biological aging
- Polypharmacy and anticholinergic burden are linked to accelerated biological aging in older adults.
- Systemic inflammation partially mediates the association between polypharmacy/anticholinergic burden and biological aging.
- The study used data from the National Health and Nutrition Examination Survey (1999-2018) involving 10,556 older adults.
- 35% of participants had polypharmacy (5-9 drugs), and 5.5% had hyperpolypharmacy (10+ drugs).
- Biological aging was measured using PhenoAge, KD-BioAge, AnthroAge, frailty index, telomere length, and α-Klotho.
- Inflammation was quantified using five blood cell-based indices, with SIRI showing significant mediation effects.
- Findings emphasize the importance of deprescribing to mitigate aging-related risks.