Short-term sleep restriction in humans alters diurnal circulating metabolite profiles, including those of microbial origin - PubMed
4 hours ago
- #microbial metabolites
- #circadian rhythms
- #sleep restriction
- Short-term sleep restriction alters diurnal circulating metabolite profiles in humans.
- Study involved 9 healthy adults in a randomized crossover design comparing normal sleep (8.5 hours/night) vs. restricted sleep (4.5 hours/night).
- 90 metabolites identified, including 14 of microbial origin or derived from host metabolism of microbial products.
- Sleep restriction disrupted rhythms of key microbial metabolites like butyrate and indole-3-propionic acid.
- New rhythms emerged in tryptophan catabolite kynurenine and lipid metabolism intermediates under sleep restriction.
- Findings suggest links between host sleep patterns and gut microbial metabolism.
- Microbial metabolites may serve as biomarkers or mediators of sleep loss-associated health risks.