Epigenetic regulation of cellular senescence - PubMed
3 hours ago
- #age-related diseases
- #epigenetics
- #cellular senescence
- Cellular senescence has dual roles: it acts as a barrier against early tumorigenesis but drives late-stage tumor progression and age-related diseases.
- Senescence is regulated by dynamic epigenetic changes, including chromatin remodeling, histone modifications, DNA methylation, and the epitranscriptome.
- Senescence exhibits heterogeneity across different diseases, being detrimental in some tissues (e.g., lung, kidney) but beneficial in others (e.g., liver fibrosis limitation).
- Epigenetic drugs targeting DNMTs, HMTs, and HDACs offer reversible therapeutic strategies for pro-senescence (cancer suppression) or anti-senescence (tissue rejuvenation).
- The review proposes leveraging epigenetic plasticity for precision medicine to target senescent cells and extend health span.