A glucocorticoid-FAS axis controls immune evasion during metastatic seeding - PubMed
3 hours ago
- #metastasis
- #glucocorticoid receptor
- #immune evasion
- Metastasis is a major cause of death in triple-negative breast cancer and other solid malignancies.
- Initial disseminated tumor cells (DTCs) evade immune surveillance via glucocorticoid receptor (GR) activation.
- GR activation represses the FAS-FASL pathway, a key cytotoxic mechanism against DTCs.
- Pharmacological GR inhibition combined with immunotherapy reduces metastatic burden and extends lifespan in mice.
- The study highlights unique immune-cancer interactions during early metastatic seeding.
- The findings suggest therapeutic opportunities to target DTCs separately from primary tumors.