Reprogramming the mitochondrial-circadian energy code with incretins - PubMed
5 hours ago
- #Metabolic Flexibility
- #Mitochondrial Function
- #Circadian Rhythms
- Mitochondrial dysfunction, circadian disruption, and cellular senescence collectively impair metabolic flexibility, a key feature of obesity and aging.
- Obesity is viewed as nutrient-driven and aging as time-driven disruptions of the mitochondrial-circadian energy code, leading to impaired energy rhythms.
- Restoring code integrity, measured by improved metabolic flexibility, should be a therapeutic goal.
- GLP-1 and dual GLP-1/GIP agonists may improve mitochondrial efficiency, align circadian rhythms, and reduce pro-senescent signaling in various tissues.
- Combination therapies like senolytics, mitophagy support, and chrono-entrainment could reprogram energy coordination and delay metabolic decline.