Effects of Glycine on Mismatch Negativity and the Underlying Theta-Band Signature in the Ketamine Model of Schizophrenia in Healthy Men - PubMed
3 days ago
- #ketamine
- #glycine
- #schizophrenia
- Pre-attentive information processing deficits are linked to poor outcomes in schizophrenia.
- Auditory mismatch negativity (MMN) is reduced in schizophrenia and related to glutamatergic dysfunction.
- Glycine, an NMDAR coagonist, was hypothesized to reverse ketamine's NMDAR-antagonistic effects.
- A placebo-controlled crossover EEG study assessed psychopathological changes in 25 participants.
- Ketamine induced schizophrenia-like symptoms and reduced MMN amplitudes, theta power, and P3a.
- Glycine prevented ketamine's effect on dMMN-associated theta power and phase consistency.
- Underlying theta power was associated with auditory alterations.
- Elevated theta activity due to glycine predicted improvement in negative symptoms.
- Results confirm the glutamate system's role in auditory processing deficits in schizophrenia.
- MMN and theta-band signature may serve as biomarkers for glutamatergic treatment benefits.