Autologous neutralizing antibodies and polyfunctional T cells contribute to long-term HIV-1 post-intervention control - PubMed
3 hours ago
- #HIV-1
- #ART-free control
- #immune response
- Autologous neutralizing antibodies and polyfunctional T cells contribute to long-term HIV-1 post-intervention control.
- Three post-intervention controllers (PICs) maintained ART-free virological control for extended periods (>6.5 years, >7.5 years, and 2.5 years).
- PICs had quantifiable genetically intact/inducible infectious proviral reservoirs, increasingly clonal and located in nongenic/centromeric chromosomal regions.
- Potent autologous neutralizing antibodies and polyfunctional HIV-1-specific CD4+ and CD8+ T cell responses persisted during ART interruption.
- Viral rebound in one PIC was associated with accumulated viral mutations escaping neutralizing antibody and T cell responses.
- Findings support developing HIV-1 curative strategies enhancing pre-existing adaptive immune responses.