Neurosenescence, inflammaging and neuroinflammation in neurodegenerative disorders - PubMed
4 hours ago
- #aging
- #inflammation
- #neurodegeneration
- Senescence is biological aging caused by genetic, metabolic, and environmental factors, leading to cell and organ deterioration.
- Immunosenescence refers to aging-related changes in immunity, causing inflammaging (low-grade inflammation) and increased susceptibility to diseases like Alzheimer's (AD) and Parkinson's (PD).
- Inflammaging involves elevated proinflammatory markers (e.g., IL-6, TGF-β) and SASP factors, observed in AD and PD patients.
- Senescence markers like p16INK4a and SASP factors (MMP-3, IL-6) are elevated in PD, alongside reduced astrocytic lamin B1.
- The review explores neurosenescence, immunosenescence in AD and PD, and potential senolytic therapies.