Metabolic control of neuroinflammation: focus on itaconate and its derivatives in CNS disorders - PubMed
3 hours ago
- #neuroinflammation
- #microglia
- #itaconate
- Microglia activation is central to neuroinflammatory and neurodegenerative diseases.
- Metabolic reprogramming regulates microglial activation, linking metabolic profiles to functional responses.
- Itaconate, produced by microglia, has antioxidant and anti-inflammatory effects.
- Itaconate impacts microglial metabolism by blocking NF-κB, activating Nrf2, and inhibiting succinate dehydrogenase and NLRP3.
- Itaconate and its derivatives show therapeutic potential in CNS disorders like stroke, Alzheimer's, and Parkinson's.
- Optimized itaconate derivatives have improved pharmacokinetics and bioactivity.
- The review explores itaconate's role in microglial regulation and its therapeutic applications.