USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion - PubMed
5 days ago
- #DNA repair
- #Ubiquitin-proteasome system
- #Huntington's disease
- USP7 deubiquitinase stabilizes FAN1, preventing its proteasomal degradation.
- USP7 depletion reduces FAN1 chromatin association and increases cellular hypersensitivity to DNA interstrand crosslink (ICL) damage.
- Loss of USP7 accelerates CAG repeat expansion in cells expressing mutant huntingtin (mHTT), relevant to Huntington's disease (HD).
- The study links USP7 and FAN1 in mechanisms preserving genome stability and influencing repeat instability.