Association of Glucagon-Like Peptide-1 Receptor Agonists and Suicidality: A Systematic Review - PubMed
5 days ago
- #GLP-1 receptor agonists
- #suicidality
- #systematic review
- GLP-1 receptor agonists (GLP-1 RAs) like liraglutide and semaglutide are significantly associated with increased odds of suicidal ideation.
- Liraglutide shows a reported odds ratio (ROR) of 3.26 for suicidal ideation, while semaglutide has an ROR of 1.73.
- Semaglutide and liraglutide also have higher odds ratios for reported suicidal depression (ROR = 8.81 and 3.74, respectively).
- Tirzepatide is associated with suicidal ideation, but the association is nonsignificant (ROR = 1.49).
- No significant association was found between other GLP-1 RAs and suicidality.
- The study does not establish causality between GLP-1 RA exposure and suicidality.