The Crohn's disease-related RNF123 prevents NLRP3 inflammasome assembly by catalyzing unanchored K63-linked ubiquitination on NEK7 - PubMed
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- #NLRP3 inflammasome
- #Crohn's disease
- #K63-linked ubiquitination
- RNF123-R854H SNP associated with Crohn's disease worsens colitis via the NLRP3-dependent pathway.
- RNF123 deficiency exacerbates inflammatory conditions like colitis, endotoxemia, and peritonitis, while enhancing bacterial defense via NLRP3.
- RNF123 regulates NLRP3 inflammasome by catalyzing unanchored K63-linked ubiquitination on NEK7, preventing NLRP3 inflammasome assembly.
- NEK7-captured unanchored K63-polyubiquitin chains act as a brake to limit excessive NLRP3 inflammasome activation, maintaining immune homeostasis.
- Study provides insights into NLRP3 inflammasome regulation and its role in inflammatory diseases.