Cerebral organoid exosomes reversed behavioral deficits by repressing NLRP3-mediated neuroinflammation in stress models - PubMed
a day ago
- #depression
- #exosomes
- #neuroinflammation
- Cerebral organoid-derived exosomes (OExos) show potential in treating depression by modulating neuroinflammation.
- OExos regulate the NLRP3 inflammasome cascade, reducing neuroinflammation in depression models.
- In vitro, OExos suppress NLRP3 inflammasome activation and microglial polarization, preventing neurotoxic astrocyte activation and synaptic loss.
- In chronic mild stress (CMS) models, intranasal OExo delivery reduces hippocampal NLRP3 activation and pro-inflammatory cytokines.
- OExo treatment alleviates CMS-induced anxiety, anhedonia, and depressive-like behaviors.
- The findings support the therapeutic potential of OExos in depression by targeting NLRP3-mediated neuroinflammation.