Extensive enhancer crosstalk controls PPARG2 activation during adipogenesis - PubMed
3 hours ago
- #PPARγ
- #Enhancer Crosstalk
- #Adipogenesis
- PPARγ is the master regulator of adipogenesis, controlling cell fate transitions.
- The study deciphers the regulatory mechanisms of enhancers driving PPARG activation during adipocyte differentiation.
- Nine individual enhancers were systematically deleted to understand their roles in PPARG expression.
- Enhancer E + 102 is crucial for PPARG activation, playing a dual role in cis crosstalk and feedback activation.
- Non-coding genetic variants linked to cardiometabolic traits map to essential enhancers in the PPARG locus.
- The findings highlight the importance of enhancer crosstalk in human physiology and disease.