A composite hydrogel enables the spatiotemporal delivery of distinct cytokines to drive the native vascularized bone regeneration - PubMed
7 hours ago
- #angiogenesis-osteogenesis coupling
- #bone regeneration
- #hydrogel delivery
- Composite hydrogel designed for spatiotemporal delivery of cytokines PCSK9 and VEGF.
- PCSK9 promotes osteogenic differentiation via ERK pathway; VEGF supports early vascularization.
- Hydrogel combines vascular-derived ECM for PCSK9 and GelMA for VEGF, mimicking natural bone healing.
- System enhances vascularized bone regeneration in vitro and in vivo, addressing bone defect challenges.
- Provides new therapeutic targets and strategies for clinical bone defect management.