Neutrophil reprogramming underlie vasculopathy and lung disease in systemic sclerosis - PubMed
4 hours ago
- #HMGB1 EVs
- #neutrophil reprogramming
- #systemic sclerosis
- Neutrophils in systemic sclerosis (SSc) show activation, granule mobilization, NET byproduct elevation, and upregulated TIE2 expression.
- Neutrophils undergo metabolic reprogramming with increased autophagy to meet energy demands, unlike in SLE where autophagy is minimal.
- HMGB1+ extracellular vesicles (EVs) from SSc plasma induce neutrophil autophagy, TIE2 expression, lung inflammation, and fibrosis.
- HMGB1 inhibitors, RAGE receptor, and recombinant HMGB1 play key roles in neutrophil reprogramming and lung injury.
- Targeting neutrophils with liposome-encapsulated clodronate prevents EV-induced effects, highlighting therapeutic potential.