Astrocytic APOE3-Christchurch expression ameliorates brain amyloid-β pathology in 5xFAD mice - PubMed
4 hours ago
- #APOE3-Christchurch
- #Alzheimer's Disease
- #Amyloid Pathology
- The APOE3-Christchurch (APOE3Ch) variant is linked to resistance against certain forms of Alzheimer's disease.
- Astrocyte-specific expression of APOE3Ch in 5xFAD mice reduced amyloid burden, neuritic dystrophy, and gliosis compared to controls.
- APOE3Ch expression lowered oligomeric Aβ levels and promoted formation of more compact, fibrillar plaques, suggesting a less toxic aggregation profile.
- Transcriptomic analysis showed downregulation of immune-related and proteostatic pathways in cortical tissue.
- Findings support APOE3Ch as a potential therapeutic modifier for Alzheimer's disease by attenuating Aβ pathology and related toxicity.