Multimorbidity phenotypes and associated characteristics in severe asthma: an observational study of European severe asthma registries - PubMed
6 days ago
- #Phenotypes
- #Multimorbidity
- #Severe Asthma
- Multimorbidity in severe asthma is poorly understood, prompting a study to define phenotypes and characteristics across Europe.
- Data from 2690 severe asthma patients across 11 countries identified three consistent comorbidity clusters: osteoporosis with steroid-induced weight gain, eczema with rhinitis, and chronic sinusitis with nasal polyps.
- Four additional comorbidities (obesity, bronchiectasis, gastro-oesophageal reflux disease, psychological factors) showed variable clustering patterns.
- Four multimorbidity phenotypes (MMPs) were identified: MMP sn (sinonasal-associated), MMP u (no specific cluster alignment), MMP ster (steroid-associated), and MMP max (maximal multimorbidity).
- MMP ster had the highest maintenance oral steroid use, worst lung function, asthma control, and exacerbation frequency.
- MMP max showed high prevalence of variably assigned comorbidities and increased need for m-OCS and biologic treatments.
- The study highlights the importance of recognizing these phenotypes to improve personalized care for severe asthma patients.
- Funding was provided by the European Respiratory Society and several pharmaceutical companies.