Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in C. elegans - PubMed
3 hours ago
- #C. elegans
- #meiosis
- #double-strand breaks
- Meiotic double-strand breaks (DSBs) are crucial for genetic exchange during gamete formation.
- Spo11, a topoisomerase-like enzyme, catalyzes DSBs, regulated by 'Spo11 accessory factors'.
- Accessory factors are poorly conserved, suggesting species-specific functions.
- Study in C. elegans reveals HIM-5 as key for X-chromosome-specific crossovers.
- HIM-5's nuclear retention depends on DSB-1, which interacts directly with SPO-11.
- HIM-5 mediates interactions among accessory factor subgroups, linking DNA loops to chromosome axes.