Measuring blood-brain barrier dysfunction: a critical appraisal of fluid biomarkers, in vitro models, in vivo imaging, and post-mortem approaches - PubMed
4 hours ago
- #neurological disorders
- #blood-brain barrier
- #research methods
- The blood-brain barrier (BBB) regulates molecular exchange between blood and brain, maintaining CNS homeostasis.
- BBB dysfunction is linked to aging and neurological disorders like Alzheimer's disease, stroke, and multiple sclerosis.
- Various methods are used to study BBB, including cell-based models, imaging techniques, and fluid biomarkers, each with strengths and limitations.
- The review critically evaluates methods for assessing BBB dysfunction, providing guidance on technique selection and data interpretation.
- Challenges include the need for standardized protocols and interdisciplinary integration of findings.
- The review emphasizes defining the specific BBB aspect under study and combining approaches for better research quality and clinical translation.