NAC promotes co-translational protein folding at the ribosomal tunnel exit - PubMed
3 hours ago
- #co-translational protein folding
- #NAC
- #chaperone
- NAC (nascent polypeptide-associated complex) promotes co-translational protein folding at the ribosomal tunnel exit.
- NAC recognizes emerging segments enriched in hydrophobicity and α-helical propensity within folded domains of cytonuclear proteins.
- Single-molecule and structural analyses show NAC's β-barrel domain dynamically interacts with nascent chains, promoting on-pathway folding.
- NAC plays a role in targeting proteins to the endoplasmic reticulum and in mitochondrial membrane protein biogenesis.
- Human NAC acts as a bona fide co-translational chaperone, expanding its functional repertoire in protein biogenesis.