The brain-gut-skin axis in inflammatory and disfiguring skin diseases: mechanistic insights, clinical correlations, and therapeutic strategies - PubMed
4 hours ago
- #integrative medicine
- #inflammatory skin diseases
- #brain-gut-skin axis
- The brain-gut-skin axis (BGSA) is crucial in inflammatory and disfiguring skin diseases like acne, atopic dermatitis, psoriasis, rosacea, vitiligo, and alopecia areata.
- These conditions are now understood as systemic, linked to neuroendocrine stress, gut microbial dysbiosis, and chronic inflammation.
- Interorgan communication involves microbial metabolites, cytokine networks, neuropeptides, and HPA axis signaling.
- Therapeutic strategies include microbiome-directed interventions (probiotics, postbiotics, dietary changes, fecal microbiota transplantation) and psychoneuroimmunological approaches.
- Integrative therapies like traditional herbal medicine show promise but require more mechanistic and clinical validation.
- Future research should focus on longitudinal multi-omics analyses and standardized clinical trials for precision management.