HE4 drives PD-L1 expression in myeloid cells via IFN-γR-JAK-STAT3 signaling to promote tumor immune evasion - PubMed
3 hours ago
- #tumor immune evasion
- #PD-L1 expression
- #HE4 biomarker
- HE4 promotes PD-L1 expression in myeloid cells through the IFN-γR-JAK-STAT3 signaling pathway, aiding tumor immune evasion.
- HE4 binds directly to IFN-γ receptors, activating JAK-STAT3 signaling and increasing PD-L1 transcription.
- Monoclonal antibodies targeting HE4 reduce myeloid PD-L1, enhance CD8+ T cell activity, and suppress tumor growth with fewer immune-related adverse events than PD-1 blockade.
- High HE4 levels correlate with poor prognosis but better response to PD-1 inhibitors in lung adenocarcinoma, suggesting dual roles as a therapeutic target and biomarker.