Sparcl1 mitigates abdominal aortic aneurysm through inhibiting lymphangiogenesis-mediated TLS formation - PubMed
3 hours ago
- #lymphangiogenesis
- #abdominal aortic aneurysm
- #Sparcl1
- Sparcl1 (Sc1) mitigates abdominal aortic aneurysm (AAA) by inhibiting lymphangiogenesis-mediated tertiary lymphoid structure (TLS) formation.
- Vascular tissue-resident macrophages (VRMs) expressing Lyve1 protect against AAA by secreting Sc1.
- Deletion of Sc1 in VRMs promotes dysfunctional lymphangiogenesis and TLS formation, accelerating AAA progression.
- The calcium-binding domain of Sc1 traps FGF2, inhibiting FGF2-mediated lymphangiogenesis and TLS-related gene expression.
- A therapeutic peptide derived from Sc1 (Spa17) shows potential in mitigating AAA progression in multiple models.