Exercise-induced extracellular vesicles protect against diabetes
5 days ago
- #exercise
- #diabetes
- #extracellular vesicles
- Exercise releases extracellular vesicles (EVs) that mediate intercellular communication and organ crosstalk.
- Study I compared EVs from continuous aerobic training (CAT) and high-intensity interval training (HIIT), showing different regulatory effects on neuronal signaling, autophagy, and cell fate.
- CAT preferentially modulates cognitive function and substrate metabolism, while HIIT is associated with organ growth, cardiac function, and insulin signaling.
- Study II found that exercise-induced EVs protect pancreatic B-cells by alleviating endoplasmic reticulum stress-induced apoptosis, primarily through miR-124-5p from the central nervous system.
- Study III engineered EVs for efficient cellular delivery using DNA nanotechnology, developing a miRNA detection-amplification system (miRDAS) for real-time monitoring of miRNA dynamics.
- The thesis provides insights into the role of exercise-induced EVs in health benefits, B-cell protection, and potential therapeutic applications.