Multi-omic profiling defines three distinct molecular subtypes of urothelial carcinoma with implications for precision therapy - PubMed
3 days ago
- #precision therapy
- #molecular classification
- #urothelial carcinoma
- Multi-omic profiling identifies three molecular subtypes of urothelial carcinoma (UC).
- Cluster #1: High-risk, stroma-rich, responsive to cytotoxic drugs, ferroptosis inducers, and PARP inhibitors.
- Cluster #2: Aggressive, fast-proliferating, immune-infiltrated, responsive to cytotoxic agents and EGFR/ERBB- and MEK/ERK-targeting therapies.
- Cluster #3: Predominantly luminal papillary phenotype, low-risk, responsive to epigenetic drugs or EGFR/FGFR inhibitors.
- The classification framework is applicable to transcriptomic and proteomic data from NMIBC, MIBC, and UC cell lines.
- The study provides a basis for personalized risk assessment and clinical trial design in UC.