Identification of novel biomarkers for Alzheimer's disease: A deep learning omics-based approach to drug pair discovery and exploration of potential therapeutic targets - PubMed
3 hours ago
- #Alzheimer's disease
- #immune dysregulation
- #drug repurposing
- The study shifts focus from Aβ/tau pathology to immune dysregulation in early Alzheimer's disease stages.
- Identified 59 plasma proteins and 65 immune cell types linked to Alzheimer's via Mendelian randomization.
- CD8+ T cells, especially CD8+CD28+CD45RA+ T cells, have a protective effect against Alzheimer's.
- Fc gamma receptor 3A (CD16a) expression correlates with CD8+ T-cell infiltration and disease progression in 5×FAD mice.
- Fc gamma receptor 3A mediates the effects of CD8+ T cells on Alzheimer's risk.
- Higher Fc gamma receptor 3A gene expression in Alzheimer's patients compared to mild cognitive impairment and normal individuals.
- Molecular docking identified 19 candidate drugs targeting Fc gamma receptor 3A.
- Proposes immune-based therapeutic strategies and an omics-based drug discovery framework for Alzheimer's.