Interaction of HIF-1a with various cell death pathways in tumor immune microenvironment (TIME) - PubMed
7 hours ago
- #Tumor Immune Microenvironment
- #Cell Death Pathways
- #HIF-1α
- HIF-1α is a key mediator of tumor adaptation to hypoxic stress.
- HIF-1α modulates multiple regulated cell death pathways and shapes the tumor immune microenvironment (TIME).
- The interaction between HIF-1α and cell death pathways influences immune evasion and therapeutic resistance.
- A systematic review was conducted following PRISMA guidelines to explore the crosstalk between HIF-1α and cell death mechanisms in TIME.
- Seventy studies were included, showing HIF-1α promotes immunosuppressive TIME elements and inhibits apoptosis while modulating pyroptosis and ferroptosis.
- Understanding HIF-1α's role in TIME and cell death provides insights into tumor adaptability and immune resistance.
- Targeting the HIF-1α axis may enhance the efficacy of cancer immunotherapies, especially in hypoxic tumors.