Molecular Mechanisms of Dopaminergic Neuron Degeneration in Parkinson's disease: A Comprehensive Review - PubMed
3 hours ago
- #dopamine
- #alpha-synuclein
- #neurodegeneration
- Parkinson's disease (PD) is characterized by dopaminergic neuron degeneration leading to dopamine depletion, causing motor and cognitive impairments.
- Pathogenesis involves α-synuclein aggregation forming Lewy bodies, lysosomal/autophagy dysfunction, mitochondrial issues, and calcium homeostasis disruption.
- Cell death mechanisms in PD include caspase-mediated apoptosis, autophagic cell death, and ferroptosis.
- Risk factors encompass genetic variations and environmental toxins contributing to brain lesions.
- Potential treatments focus on antioxidants, autophagy modulation, gene therapy, and stem cell regeneration.