The association between low hemoglobin-to-red blood cell distribution width ratio and macroalbuminuria in diabetic kidney disease: evidence from NHANES and an external validation cohort - PubMed
4 hours ago
- #Hemoglobin-to-Red Cell Distribution Width Ratio
- #Diabetic Kidney Disease
- #Macroalbuminuria
- The study explores the association between low hemoglobin-to-red blood cell distribution width ratio (HRR) and macroalbuminuria in diabetic kidney disease (DKD).
- Using NHANES data (1999-2018), DKD was diagnosed based on eGFR <60 mL/min/1.73 m² or UACR ≥30 mg/g in diabetic patients.
- HRR levels were significantly lower in the macroalbuminuria group compared to the microalbuminuria group (0.96 ± 0.19 vs. 1.01 ± 0.18, p < 0.001).
- Elevated HRR was associated with a significant decrease in UACR (95% CI: 0.058-0.274, p < 0.001).
- Quartile analyses showed a significant trend, with higher HRR linked to lower odds of macroalbuminuria (Q4 vs. Q1, OR: 0.421, 95% CI: 0.284-0.620, p < 0.001).
- HRR may serve as an effective inflammatory marker for identifying macroalbuminuria in DKD.