Cytotoxic Vδ2+ T cell subsets expand in response to malaria in human tonsil and spleen organoids - PubMed
3 hours ago
- #Vδ2 T cells
- #malaria
- #organoids
- Cytotoxic Vδ2+ T cell subsets expand in human tonsil and spleen organoids exposed to Plasmodium falciparum-infected red blood cells.
- Single-cell sequencing shows these Vδ2+ T cells are clonally expanded and exhibit activated, cytotoxic phenotypes with upregulated granzymes and interferon-stimulated genes.
- Validation using tonsils from Ugandan children with asymptomatic malaria reveals expanded Vδ2+ T cells with enhanced cytotoxic potential compared to uninfected controls.
- Malaria pre-exposure does not significantly alter subsequent recall responses to influenza vaccine in most donors, though modest reductions occur in some individuals.
- Human lymphoid organoids are useful for studying malaria-host interactions and provide insights into Vδ2+ T cell clonal expansion and differentiation in secondary lymphoid tissues.