Impact of COVID-19 vaccination on post-COVID syndrome across clinical definitions and phenotypes: a prospective multicenter cohort study - PubMed
3 hours ago
- #Clinical phenotypes
- #Post-COVID syndrome
- #COVID-19 vaccination
- COVID-19 vaccination reduces risk of post-COVID syndrome (PCS) across multiple clinical definitions.
- Vaccination significantly lowers PCS risk per WHO definition, PCS score, and Respiratory/Cognitive Clusters, but not Fatigue Cluster.
- Protective effect of vaccination is notable in patients with mild acute symptoms, regardless of hospitalization.
- The study highlights the need for phenotype-oriented PCS definitions to reflect clinical heterogeneity and vaccination responses.
- Findings suggest different PCS phenotypes may have distinct pathophysiological mechanisms.