PrPC Glycoprotein Modulates Atmospherically Relevant Artificial Particulate Matter-Induced Development of Lung Cancer in Mice - PubMed
6 hours ago
- #PM2.5
- #Aging
- #Lung Cancer
- PM2.5 exposure is an environmental risk factor for lung cancer, with mechanisms unclear.
- PrPC glycoprotein regulates susceptibility to PM2.5-induced lung pathologies in mice.
- Aged mice show lower PrPC and Sirt1, higher HIF-1α, and increased cancer susceptibility.
- PrPC deficiency exacerbates age-related lung damage, promoting emphysema and tumorigenesis via Sirt1-p53-HIF1α dysregulation.
- NIST 1648a urban standard PM2.5 causes more aggressive tumorigenesis than synthetic mixtures.
- PrPC is a potential biomarker for pollution-associated lung cancer, especially in older adults.