Compound Kushen injection improves M1 macrophage polarisation and radiation-induced colitis by regulating Piezo1-mediated NF-κB/NLRP3 pathway - PubMed
7 hours ago
- #Compound Kushen injection
- #Radiation-induced colitis
- #Macrophage polarization
- Compound Kushen injection (CKI) improves radiation-induced colitis (RIC) by regulating macrophage polarization.
- CKI enhances survival, reduces inflammation, and protects intestinal barrier in irradiated mice.
- Mechanistically, CKI inhibits Piezo1 activation in macrophages, reducing NF-κB/NLRP3 pathway signaling.
- Macrophage-specific Piezo1 ablation diminishes CKI's therapeutic effects, confirming its role in RIC improvement.
- CKI presents a potential therapeutic target for managing radiation-induced colitis.