Suramin directly targets PI3K to alleviate experimental colitis by restoring intestinal barrier and activating autophagy - PubMed
4 days ago
- #Suramin
- #Autophagy
- #PI3K
- Suramin alleviates experimental colitis by targeting PI3K.
- Restores intestinal barrier integrity by increasing tight junction proteins (ZO-1, Occludin, Claudin-1).
- Enhances autophagic flux in colonic tissues.
- Directly interacts with the p85α regulatory subunit of PI3K, inhibiting the PI3K/AKT/mTOR pathway.
- PI3K reactivation abolishes suramin's protective effects, worsening inflammation and barrier failure.
- Identified as a potential drug repurposing candidate for ulcerative colitis (UC).