Hematopoietic Cell Kinase Promotes Cerebral Ischemic Injury and Mitochondrial Dysfunction via p38 Activation in Ischemic Stroke - PubMed
4 hours ago
- #Ischemic Stroke
- #Neuroprotection
- #Mitochondrial Dysfunction
- HCK identified as a key regulatory factor in ischemic stroke via bioinformatics analysis and PPI network construction.
- HCK upregulation observed in rat MCAO models and OGD-treated N2a cells; knockdown reduces injury and mitochondrial dysfunction.
- Mechanistic insights show HCK acts upstream of p38, activating it to mediate OGD-induced neuronal injury and mitochondrial issues.
- Study highlights HCK as a promising therapeutic target for neuroprotection in ischemic stroke.