NFAT1+ microglia promote antiinflammatory polarization and angiogenesis via the HAS3-HA-LYVE1 axis to improve ischemic stroke outcomes - PubMed
3 hours ago
- #ischemic stroke
- #microglia
- #NFAT1
- NFAT1+ microglia promote anti-inflammatory polarization and angiogenesis via the HAS3-HA-LYVE1 axis to improve ischemic stroke outcomes.
- NFAT1 deficiency worsens neurological function, increases neuronal damage, and reduces anti-inflammatory and pro-angiogenic factors.
- NFAT1 upregulates HAS3 and LYVE1, promoting HA-LYVE1 autocrine/paracrine signaling and activation of the Wnt/β-catenin pathway.
- Conditioned medium from Nfat1+/+ microglia enhances endothelial cell proliferation, migration, and tube formation.
- NFAT1-overexpressing microglia therapy improves neurological recovery and reduces infarct size in stroke mice.
- Microglial NFAT1 drives anti-inflammatory polarization and angiogenesis, highlighting its potential as a therapeutic target for ischemic stroke.