Irreversible Electroporation Enhances Solid Tumor Infiltration and Selective Cancer Cell Lysis by CAR T Cells - PubMed
10 hours ago
- #solid tumor
- #CAR T-cell therapy
- #irreversible electroporation
- Irreversible electroporation (IRE) enhances CAR T-cell infiltration into solid tumors by creating a chemokine gradient.
- Selective IRE (sIRE) is optimized to lyse cancer cells while sparing infiltrating T cells, allowing repeated use.
- In mouse models, sIRE promoted CAR T-cell migration, infiltration, and sustained anti-tumor immunity.