Cellular Anti-Apoptotic Effects of Dapagliflozin in Methotrexate-Induced Liver Toxicity: Bax/Bcl-2/Cyt-C/Cas-9/Cas-3 Signaling Pathway - PubMed
4 hours ago
- #apoptosis
- #hepatoprotection
- #inflammation
- Dapagliflozin (DAPA) shows hepatoprotective effects against Methotrexate (MTX)-induced liver injury.
- MTX causes liver damage through oxidative stress, inflammation, and apoptosis, which DAPA mitigates.
- The study involved 32 rats divided into four groups to assess DAPA's effects on MTX-induced liver toxicity.
- DAPA treatment restored liver structure and reduced inflammatory and apoptotic markers like NF-κB, TNF-α, IL-1β, and Bax.
- DAPA also normalized VEGF expression, indicating reduced pathological angiogenesis.
- The findings suggest DAPA as a promising adjunct therapy to reduce MTX-induced liver damage.