Evaluation of Therapeutic Effects and Underlying Mechanisms of Baichuan Baile Formula in Rodent Insomnia Models - PubMed
3 hours ago
- #dietary supplement
- #insomnia
- #neuroinflammation
- Baichuan Baile (BCBL) is a novel functional dietary formula with potential antidepressant-like effects via modulation of the 5-HT system.
- BCBL shows therapeutic efficacy in rodent insomnia models, improving sleep through behavioral and EEG evaluations.
- Mechanisms include anti-inflammatory effects, neurotransmitter rebalancing (serotonin, dopamine, adenosine, glutamate), and stabilization of circadian rhythm genes (BMAL1, PER2, CLOCK).
- BCBL mitigates stress-induced sleep impairments, protects against serotonin depletion effects, and reduces hippocampal levels of inflammatory markers (HIF-1α, TNF-α, IL-1β).
- The formula enhances SIRT1 expression and modulates the p-GSK3β/GSK3β ratio in the hypothalamus, contributing to its sleep-promoting properties.