Functional xenogeneic hematopoietic cells maintaining donor-dominant identity and immune tolerance enable therapy - PubMed
6 hours ago
- #Interspecies Chimeras
- #Hematologic Therapies
- #Xenogeneic Hematopoiesis
- Study generates xenogeneic hematopoietic cells in interspecies chimeras to address shortages in clinical supply.
- Bone marrow transplantation achieved higher chimeric efficiency than blastocyst complementation in rodent models.
- Xenogeneic cells (RBCs, platelets, WBCs) showed donor-dominant transcriptional and proteomic profiles and did not cause significant immune rejection.
- Reverse transplantation into disease models demonstrated functional efficacy: RBCs rescued hemorrhagic anemia and thalassemia, platelets alleviated thrombocytopenia, and engineered T cells suppressed leukemia.
- Implantation partially restored splenic morphology and function in immunodeficient recipients.
- Research establishes a paradigm for using interspecies bioreactors to produce functional, immune-tolerant cells for hematologic therapies.