Skin inflammation and itch response are independently regulated by distinct nociceptor subsets - PubMed
3 hours ago
- #itch-inflammation regulation
- #nociceptor subsets
- #neuroimmunology
- A subset of MrgprD+ nonpeptidergic neurons controls itch but not inflammation in allergic contact dermatitis (ACD).
- A subset of Trpv1+ peptidergic neurons regulates skin inflammation by influencing neutrophilic infiltration, independent of itch.
- Retrograde axonal tracing combined with single-cell RNA sequencing identified distinct nociceptor subsets with adaptive, nonredundant roles.
- Selective ablation of MrgprD+ neurons eliminates itch-evoked behavior without affecting skin inflammation.
- Depletion of Trpv1+ neurons exacerbates inflammation but does not alter itch responses.