The heterogeneous treatment effects of statins on dementia: a target trial emulation with causal machine learning using integrated genetic and real-world data - PubMed
3 hours ago
- #genetics
- #statins
- #dementia
- Study examines heterogeneous treatment effects (HTEs) of statins on dementia using causal machine learning.
- Target trial emulation with UK Biobank data compared statin initiators and non-initiators aged ≥55 years.
- Overall, statins showed a non-significant adjusted risk difference (aRD) of -1.0‰ for all-cause dementia.
- Subgroups identified by non-APOE polygenic risk score (PRS) showed cognitive benefits from statins.
- High non-APOE PRS participants had significant aRD reductions: -5.9‰ for all-cause dementia and -5.0‰ for Alzheimer's disease.
- Findings suggest genetic susceptibility beyond APOE may influence statins' cognitive effects.