Oxysterols at the Crossroads of Cholesterol Metabolism and Cancer - PubMed
3 hours ago
- #Cancer Metabolism
- #Oxysterols
- #Cholesterol Signaling
- Oxysterols are cholesterol derivatives involved in lipid homeostasis, nuclear receptor signaling, oxidative stress, and immunity.
- They exhibit diverse biological activities, regulating sterol trafficking, autophagy, redox balance, and membrane organization.
- In cancer, oxysterols have dual roles: some (e.g., dendrogenin A) promote anticancer immunity, while others (e.g., 27-hydroxycholesterol, oncosterone) support tumor growth and immune evasion.
- The 5,6-epoxycholestanol pathway can lead to either anticancer (dendrogenin A) or pro-tumor (OCDO) metabolites.
- CYP27A1 hydroxylates oncogenic OCDO into an antiproliferative metabolite, adding complexity to oxysterol signaling.
- Oxysterol metabolism influences tumor progression, immune surveillance, and cellular plasticity, offering potential therapeutic targets.