Decoding GPX4 regulation in ferroptosis: mechanisms and therapeutic implications - PubMed

7 hours ago

Ferroptosis is a regulated form of cell death driven by iron-dependent lipid peroxidation.
GPX4, a selenoenzyme, detoxifies phospholipid hydroperoxides and acts as a key regulator of ferroptosis.
GPX4 is involved in various pathologies, including cancer, neurodegeneration, acute renal failure, and infection.
GPX4 regulation occurs at multiple levels: transcription, mRNA stability, and post-translational modifications.
Post-translational modifications affecting GPX4 include ubiquitination, phosphorylation, palmitoylation, methylation, hydroxylation, and lactylation.
Therapeutic strategies targeting GPX4 include ferroptosis inducers for cancer therapy and inhibitors to prevent ferroptosis-related damage.

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