Anti-MDA5 Antibody-Positive Dermatomyositis in Emirati Patients: A Case Series Highlighting Clinical Variability - PubMed
4 days ago
- #interstitial lung disease
- #dermatomyositis
- #autoimmune disease
- Anti-MDA5 dermatomyositis (MDA5-DM) is a rare autoimmune disease linked to rapidly progressive interstitial lung disease (RP-ILD).
- Three Emirati patients with MDA5-DM presented different clinical pictures, organ involvement, and outcomes.
- Case 1: A 24-year-old man with RP-ILD died despite aggressive treatment including ECMO.
- Case 2: A 62-year-old man with ILD stabilized with steroids, rituximab, and other therapies but required long-term oxygen.
- Case 3: A 13-year-old boy with myositis improved after steroids and IV immunoglobulin, achieving full recovery.
- MDA5-DM has a broad clinical spectrum, from mild skin-limited disease to life-threatening RP-ILD.
- Multidisciplinary care and research into disease mechanisms are crucial for improving MDA5-DM survival.