Nanotechnology-Assisted Molecular Profiling: Emerging Advances in Circulating Tumor DNA Detection - PubMed
4 hours ago
- #liquid biopsy
- #nanotechnology
- #cancer diagnostics
- Nanotechnology is enhancing the detection of circulating tumor DNA (ctDNA), a key biomarker for non-invasive cancer diagnosis and monitoring.
- Challenges in ctDNA detection include its low abundance, high fragmentation, and rapid degradation, requiring highly sensitive and specific assays.
- Recent advances include surface-engineered nanomaterials for selective enrichment, nano-enabled signal amplification, and integrated platforms like CRISPR, microfluidics, and nanopore technologies.
- Nanostructure-based approaches are improving the analysis of methylation, fragmentation profiles, and multi-omics signatures for early cancer detection and therapeutic assessment.
- Artificial intelligence (AI) is being increasingly used in nanostructure characterization, aptamer design, multi-omics data integration, and algorithm development to advance liquid biopsy.
- Challenges for clinical translation include standardization, biocompatibility, automation, and regulatory readiness.
- The convergence of nanotechnology and AI is driving progress in ctDNA-based precision oncology.