Translocation of bacteria from the gut to the brain in mice - PubMed
a day ago
- #gut-brain axis
- #bacterial translocation
- #neurological diseases
- Bacteria can translocate from the gut to the brain in mice fed a high-fat atherogenic diet (Paigen diet).
- The vagus nerve serves as a conduit for bacterial translocation, as shown by reduced brain bacterial burden after cervical vagotomy.
- Antibiotic treatment alters gut microbiome composition and affects which bacteria localize to the brain.
- Exogenous Enterobacter cloacae introduced via gavage was detected in both the gut and brain of mice on the Paigen diet.
- Germ-free mice monocolonized with E. cloacae showed bacterial presence in the brain only when fed the Paigen diet, not standard diet.
- Bacterial translocation to the brain is reversible upon returning to a normal diet.
- Bacteria were also found in the brains of mouse models for Alzheimer's, Parkinson's, and autism spectrum disorder, even on standard diets.
- The study suggests a gut-to-brain bacterial translocation axis influenced by diet and genetics, potentially relevant to neurological conditions.